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. 2010 Oct 25;20(2):294–300. doi: 10.1093/hmg/ddq464

Figure 5.

Figure 5.

Meclizine rescues photoreceptor loss in a fly model of polyQ toxicity. (A and B) Transgenic human N-548-Htt-Q128 transgene driven in photoreceptors using elav-GAL4 resulted in time-dependent neurodegeneration as assessed by the number of visible rhabdomeres. (A) Flies expressing mutant N-548-Htt-Q128 have normal complement of seven visible light collecting units (rhabdomeres) per ommatidium at day 0 post-eclosion. (B) Number of rhabdomeres at day 10 post-eclosion. (C) Western blot analysis of lysates from elav-GAL > UAS-N-548-Htt-Q128 adult flies that had been fed on either 33 µm meclizine or DMSO for 10 days. (D) Flies were treated with DMSO vehicle or meclizine at 33 µm for 10 days and the average number of rhabdomeres per ommatidium was calculated and is shown as a distribution. Data expressed as the mean ± SD (n = 2, *P < 0.05).