Table 1.

Classification of age-related genes according to Gene Ontology(GO) terms.

Order	Cellular component	No. genes	Molecular function	No. genes	Biological process	No. genes
1	Nucleus	408	protein binding	435	regulation of transcription, DNA-dependent	117
2	cytoplasm	391	nucleotide binding	160	signal transduction	98
3	membrane	163	metal ion binding	137	transcription	82
4	plasma membrane	155	zinc ion binding	131	anti-apoptosis	48
5	extracellular region	150	ATP binding	123	cell cycle	47
6	cytosol	137	transferase activity	95	interspecies interaction between organisms	44
7	mitochondrion	107	transcription factor activity	85	apoptosis	44
8	integral to membrane	107	DNA binding	78	response to DNA damage stimulus	43
9	intracellular	106	calcium ion binding	64	multicellular organismal development	42
10	nucleolus	86	hydrolase activity	56	cell adhesion	38