Table 1.

Summary of some putative functions of mPFC (prelimbic and infralimbic), lPFC, ACC and OFC from rat and human studies.

	Rat		Human
Brain Region	Putative Functions	Example References	Putative Functions	Example References
mPFC	Reward processing Attention Impulsivity Drug reinstatement (prelimbic) Habit learning (infralimbic)	Bardo et al. (1996) Cardinal et al. (2001) Coutureau and Killcross (2003) McLaughlin and See (2003)	Reward processing Attention Conflict decision making	Kerns et al. (2004) Ridderinkhof et al. (2004a)
lPFC	N/A	N/A	Decision making Attentional gating Behavioral inhibition Working memory Emotion regulation	Fuster (2008) Shackman et al. (2009) Wager et al. (2008)
ACC	Attention Discrimination learning Timing of reward Drug reinstatement	Dalley et al. (2004) Dietrich and Allan (1998) McFarland et al. (2004)	Attention Emotional processing Self-Monitoring Processing of social stimuli	Fuster (2008) Kringelbach and Rolls (2004) Posner et al. (2007)
OFC	Behavioral Inhibition Signaling expected outcomes Reversal learning	Chudasama and Robbins (2003b) Winstanley (2007) Schoenbaum and Roesch (2005)	Behavioral Inhibition Reward sensitivity (medial) Punishment sensitivity (lateral) Emotional decision-making Reversal learning	Kringelbach and Rolls (2004) Liu et al. (2007) Cools et al. (2002)

Abbreviations: mPFC, medial prefrontal cortex; lPFC, lateral prefrontal cortex; ACC, anterior cingulate cortex; OFC, orbitofrontal cortex; N/A, not applicable.