Table 1.
Biomarker Candidate ions (m/z) selected from Short-Column LCMS and LC-MS/MS analysis of urine samples from IL10−/− and wild-type (WT) mice.
| Short-Column LCMS Biomarker ion (m/z) | Average fold change Log2 (IL10−/−/WT) | P value | Early difference observed | Identification, |
|---|---|---|---|---|
| Negative ions | ||||
| 204 | 1.8 (expt. 1) | <.01 (FDR <0.05) | Y | xanthurenic acid |
| 2.5 (expt. 2) | <.01 (FDR <0.05) | |||
| 308 | −1.5 (expt. 1) | <.01 (FDR >0.05)) | ? (expt. 1) | unknown |
| −1.8 (expt. 2) | <.01 (FDR <0.05) | Y (expt. 2) | ||
| 380 | −1.1 (expt. 1) | >.01 | N (expt. 1) | xanthurenic acid glucuronide |
| −1.6 (expt. 2) | >.01 | Y (expt. 2) | ||
| 453 | −1.5 (expt. 1) | <.01 (FDR >0.05) | N (expt. 1) | α-CEHC glucuronide |
| −2.0 (expt. 2) | <.01 (FDR <0.05) | Y (expt. 2) | ||
| 495 | −1.5 (expt. 1) | <.01 (FDR >0.05) | Y (expt. 1) | unknown |
| −2.2 (expt. 2) | <.01 (FDR <0.05) | Y (expt. 2) | ||
| Positive ions | ||||
| 206 | 1.7 (expt. 1) | <.01 (FDR <0.05) | Y (expt. 1) | xanthurenic acid |
| 1.2 (expt. 2) | >.01 | N (expt. 2) | ||
| 382 | −1.2 (expt. 1) | >.01 | N (expt. 1) | xanthurenic acid glucuronide |
| −1.5 (expt. 2) | <.01 (FDR <0.05) | Y (expt. 2) | ||
| 497 | −1.2 (expt. 1) | >.01 | Y (expt. 1) | unknown |
| −1.4 (expt. 2) | <.01 (FDR <0.05) | Y (expt. 2) | ||