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. 2010 Dec 6;2011:974701. doi: 10.1155/2011/974701

Table 1.

Biomarker Candidate ions (m/z) selected from Short-Column LCMS and LC-MS/MS analysis of urine samples from IL10−/− and wild-type (WT) mice.

Short-Column LCMS Biomarker ion (m/z) Average fold change Log2 (IL10−/−/WT) P value Early difference observed Identification,
Negative ions

 204 1.8 (expt. 1) <.01 (FDR <0.05) Y xanthurenic acid
2.5 (expt. 2) <.01 (FDR <0.05)
 308 −1.5 (expt. 1) <.01 (FDR >0.05)) ? (expt. 1) unknown
−1.8 (expt. 2) <.01 (FDR <0.05) Y (expt. 2)
 380 −1.1 (expt. 1) >.01 N (expt. 1) xanthurenic acid glucuronide
−1.6 (expt. 2) >.01 Y (expt. 2)
 453 −1.5 (expt. 1) <.01 (FDR >0.05) N (expt. 1) α-CEHC glucuronide
−2.0 (expt. 2) <.01 (FDR <0.05) Y (expt. 2)
 495 −1.5 (expt. 1) <.01 (FDR >0.05) Y (expt. 1) unknown
−2.2 (expt. 2) <.01 (FDR <0.05) Y (expt. 2)

Positive ions

 206 1.7 (expt. 1) <.01 (FDR <0.05) Y (expt. 1) xanthurenic acid
1.2 (expt. 2) >.01 N (expt. 2)
 382 −1.2 (expt. 1) >.01 N (expt. 1) xanthurenic acid glucuronide
−1.5 (expt. 2) <.01 (FDR <0.05) Y (expt. 2)
 497 −1.2 (expt. 1) >.01 Y (expt. 1) unknown
−1.4 (expt. 2) <.01 (FDR <0.05) Y (expt. 2)