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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Basic Clin Pharmacol Toxicol. 2010 Sep 2;108(1):55–62. doi: 10.1111/j.1742-7843.2010.00628.x

Figure 1.

Figure 1

Methadone turnover (A). EDDP production (B) and Methadone turnover minus EDDP production (C) in cDNA-expressed CYPs (Supersomes) incubated with 750 ng/ml methadone. Specific use of (R)- and (S)-methadone and production of (R)- and (S)-EDDP is indicated by speckled and hatched bars, respectively. Results are the mean of duplicate incubations. For CYPs with higher activities (2B6 and 3A4) 10 min incubations were used; 30-min. incubations were used for other CYPs.