Table 4.
GEE Models of Specific Cognitive Decline in Healthy Elders as a function of Aβ
| Predictor | Memory | Language | Visuospatial | |||
|---|---|---|---|---|---|---|
| Baseline Aβ42 | Beta | p | Beta | P | Beta | p |
| Aβ42 (Q2) | −.03 | .02 | −.02 | .07 | −.02 | .09 |
| Aβ42 (Q3) | −.03 | .02 | −.02 | .14 | −.02 | .03 |
| Aβ42 (Q4) | −.01 | .37 | −.01 | .14 | −.02 | .09 |
| Aβ42 Change | Beta | p | Beta | p | Beta | p |
| Aβ42 (Dec/Stable) | −.02 | .06 | −.01 | .17 | −.01 | .18 |
| Baseline Aβ40 | Beta | p | Beta | p | Beta | p |
| Aβ40(Q2) | −.03 | .02 | < −.01 | .62 | −.01 | .24 |
| Aβ40(Q3) | −.02 | .09 | < −.01 | .91 | −.01 | .21 |
| Aβ40(Q4) | −.02 | .10 | −.02 | .12 | −.02 | .08 |
| Aβ40 Change | Beta | p | Beta | p | Beta | p |
| Aβ40(Dec/Stable) | −.01 | .26 | .01 | .33 | −.01 | .53 |
Note. Q = Quartile. Dec/Stable= Decreasing/Stable. The reference group for models examining baseline values is the lowest quartile. The reference group for models examining change as a predictor is increasing values. Beta values pertain to the interaction term in the GEE model (predictor * time) and reflect rate of cognitive decline in comparison to that in the reference group with negative betas indicating faster decline and positive betas indicating slower decline.