Table I.
Variable | Metoprolol Enantiomer |
Metoprolol IR 50mg |
Metoprolol ER 100mg |
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---|---|---|---|---|---|---|---|
Without paroxetine |
With paroxetine |
Without paroxetine |
With paroxetine |
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AUC0–24h | S | 138±98 | 511±116 | ** | 173±96 | 599±174 | ** |
(ng*h/mL) | R | 84±75 | 436±141 | ** | 120±71a | 521±183 | ** |
Cl/F (L/h) | S | 194±171 | 47±15 | * | 138±90b | 56±46c | |
R | 392±913 | 56±27 | * | 292±291d | 66±36c | ||
λz(h−1) | S | 0.23±0.05 | 0.13±0.02 | ** | 0.04±0.03b | 0.04±0.03c | |
R | 0.29±0.19 | 0.14±0.03 | * | 0.05±0.03d | 0.05±0.02c | ||
Tmax (h) | S | 1.0±0.4 | 1.0±0.6 | 8±3 | 10±3 | ||
R | 1.0±0.3 | 1.1±0.6 | 5±4a | 9±3 | * | ||
Cmax | S | 30±23 | 81±17 | ** | 10±5 | 35±9 | * |
(ng/mL) | R | 20±20 | 73±18 | ** | 8±4a | 30±9 | * |
S/R AUC | S/R | 1.64±0.25 | 1.17±0.17 | ** | 1.65±0.37a | 1.15±0.11 | ** |
Ratio |
Values are reported as geometric mean ± standard deviation.
P<0.05;
P<0.001;
N=9 evaluable;
N=6 evaluable;
N=5 evaluable;
N=7 evaluable