Table II.
Subject | Metoprolol Enantiomer |
Metoprolol IR 50mg |
Metoprolol ER 100mg |
||
---|---|---|---|---|---|
AUC0–24h (% change with paroxetine) |
S/R AUC Ratio (% change with paroxetine) |
AUC0–24h (% change with paroxetine) |
S/R AUC Ratio (% change with paroxetine) |
||
1 | S | 147 | −37 | 199 | −32 |
R | 294 | 338 | |||
2 | S | 303 | −44 | 204 | −41 |
R | 615 | 418 | |||
3 | S | 63 | −11 | 58 | −14 |
R | 84 | 84 | |||
4 | S | 524 | −28 | 666 | n/a* |
R | 770 | n/a* | |||
5 | S | 446 | −15 | 397 | −48 |
R | 546 | 865 | |||
6 | S | 573 | −32 | 501 | −36 |
R | 883 | 844 | |||
7 | S | 641 | −27 | 350 | −42 |
R | 909 | 674 | |||
8 | S | 64 | −17 | 117 | −17 |
R | 98 | 161 | |||
9 | S | 188 | −35 | 157 | −18 |
R | 343 | 213 | |||
10 | S | 266 | −34 | 207 | −27 |
R | 453 | 320 | |||
Mean | S | 322 | −28 | 286 | −31 |
R | 500 | 435 |
No detectable R-enantiomer plasma concentrations when metoprolol ER was given without paroxetine.