. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: J Clin Pharmacol. 2010 Apr 16;51(3):389–396. doi: 10.1177/0091270010365559

Table II.

% change from baseline in AUC_0–24h and S/R AUC ratio with paroxetine addition to metoprolol IR and metoprolol ER in healthy subjects (N=10)

Subject	Metoprolol Enantiomer	Metoprolol IR 50mg		Metoprolol ER 100mg
Subject	Metoprolol Enantiomer	AUC_0–24h (% change with paroxetine)	S/R AUC Ratio (% change with paroxetine)	AUC_0–24h (% change with paroxetine)	S/R AUC Ratio (% change with paroxetine)
1	S	147	−37	199	−32
1	R	294	−37	338	−32
2	S	303	−44	204	−41
2	R	615	−44	418	−41
3	S	63	−11	58	−14
3	R	84	−11	84	−14
4	S	524	−28	666	n/a^*
4	R	770	−28	n/a^*	n/a^*
5	S	446	−15	397	−48
5	R	546	−15	865	−48
6	S	573	−32	501	−36
6	R	883	−32	844	−36
7	S	641	−27	350	−42
7	R	909	−27	674	−42
8	S	64	−17	117	−17
8	R	98	−17	161	−17
9	S	188	−35	157	−18
9	R	343	−35	213	−18
10	S	266	−34	207	−27
10	R	453	−34	320	−27
Mean	S	322	−28	286	−31
Mean	R	500	−28	435	−31

No detectable R-enantiomer plasma concentrations when metoprolol ER was given without paroxetine.