Table 3.
Global Measures of Model Fit for All-Cause Mortality and Hospital Length of Stay (HLOS)
| Postoperative Day 1 biomarker |
Peak biomarker |
Repeated measures |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Δ −2LL | Δ AIC | Δ BIC | Δ −2LL | Δ AIC | Δ BIC | Δ −2LL | Δ AIC | Δ BIC | |
| Mortality | |||||||||
| w/o biomarkers | 56.5 | 36.5 | 13.3 | 56.5 | 36.5 | 13.3 | 43.3 | 23.3 | 3.6 |
| hFABP | 72.3* | 50.3 | 24.8 | 70.0* | 48.0 | 22.5 | 68.1* | 46.1 | 24.4 |
| Myoglobin | 58.5 | 36.5 | 11.0 | 59.2 | 37.2 | 11.7 | 66.2* | 44.2 | 22.5 |
| CKMB | 57.9 | 35.9 | 10.4 | 57.5 | 35.5 | 10.0 | 45.5 | 23.5 | 1.8 |
| cTnI | 56.9 | 34.9 | 9.4 | 56.7 | 34.7 | 9.2 | 43.7 | 21.7 | 0.0 |
| Hospital length of stay | |||||||||
| w/o biomarkers | 384.1 | 362.1 | 306.0 | 384.1 | 362.1 | 306.0 | 295.0 | 273.0 | 219.8 |
| hFABP | 393.4* | 369.4 | 308.2 | 388.6* | 364.6 | 303.4 | 314.9* | 290.9 | 232.9 |
| Myoglobin | 394.1* | 370.1 | 308.9 | 396.8* | 372.8 | 311.5 | 312.5* | 288.5 | 230.5 |
| CKMB | 393.9* | 369.9 | 308.6 | 402.1* | 378.1 | 316.9 | 300.0* | 276.0 | 218.0 |
| cTnI | 389.5* | 365.5 | 304.3 | 390.4 | 366.4 | 305.1 | 295.9 | 271.9 | 213.9 |
The predictive value of adding each biomarker individually to the baseline clinical model of all-cause mortality and HLOS is shown. Higher values indicate better fit. AIC and BIC reward the model for covariates that contribute significantly and penalizes for each additional variable (larger numbers = better model fit).
−2LL = negative two log likelihood ratio; AIC = Akaike information criterion; BIC = Bayesian information criterion; hFABP = heart-type fatty acid binding protein; cTnI = cardiac troponin I; CKMB = creatinine kinase MB fraction.
P < 0.05 is significance of biomarkers compared with baseline clinical model for the negative two log likelihood ratio in a χ2 distribution with 1 degree of freedom.