TABLE 3.

The vascular response to prazosin

Diet	Prazosin use	Maximal response, g	EC50(×10−6M)
Control	Without prazosin	2.20±0.40	0.44±1.4
	With prazosin	2.21±0.70	2.06±3.7*
U-HFD	Without prazosin	1.83±0.65	0.16±1.8
	With prazosin	1.84±0.46	5.01±1.2**

Data presented as mean ± SEM.

^*P<0.003 versus control without prazosin;

^**P<0.001 versus a high-fat diet rich in unsaturated fatty acids (U-HFD) without prazosin (n=6) (Student’s t test for paired samples). EC₅₀ Concentration necessary to produce 50% of maximal response