Table 1.
Amino acid sequences of the novel cell-penetrating peptide S41, homologues and mutations. One-letter amino acid codes are used. (A) Sequence of S41 and alignment with a region of MHCI from human (aa 128–140), rat (aa 105–117), and mouse (aa 125–137). (B) Amino acid sequences of S41 mutants created for this study.
| A | |||||||||||||
| S41 | C | V | Q | W | S | L | L | R | G | Y | Q | P | C |
| MHC Glass I Human | G | P | D | G | R | L | L | R | G | Y | N | Q | F |
| MHC class I Rat | G | T | D | W | S | L | L | R | G | Y | R | Q | D |
| MHC class I Mouse | G | S | D | W | R | L | L | R | G | Y | Q | Q | F |
| B | |||||||||||||
| S41 (wild-type) | C | V | Q | W | S | L | L | R | G | Y | Q | P | C |
| Mutant l (Ml) (C1M) | M | V | Q | W | S | L | L | R | G | Y | Q | p | C |
| Mutant 2 (M2) (W4A) | C | V | Q | A | S | L | L | R | G | Y | Q | P | C |
| Mutant 3 (M3) (S5R) | C | V | Q | W | R | L | L | R | G | Y | Q | p | C |