Skip to main content
. 2010 Dec 21;5(12):e15707. doi: 10.1371/journal.pone.0015707

Figure 4. Behavioural effects of elevated CB1 receptor levels in hippocampal pyramidal neurons and mossy cells.

Figure 4

Seizures were induced in AAV-Glu-CB1 mice (n = 15) and AAV-WT controls (n = 11) by i.p. injection of kainic acid (30 mg/kg). A, Seizure severity was reduced in AAV-Glu-CB1 mice at every time point of scoring compared to AAV-WT controls without reaching significance (p = 0.065, Mann Whitney test, two-tailed). B, The average behavioral score over a period of 120 min is significantly decreased in AAV-Glu-CB1 mice (p = 0.0007, Mann Whitney test, two-tailed) indicating improved protection against KA-induced seizures. C, Kaplan–Meier survival curves of AAV-Glu-CB1 and AAV-WT mice during KA treatment are significantly different between both genotypes (p = 0.0494, log rank test). The survival rate at 180 min after KA injection was 53% of AAV-Glu-CB1 vs. 18% of AAV-WT mice.