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. 2010 Dec 21;5(12):e15707. doi: 10.1371/journal.pone.0015707

Figure 5. Increased CB1 receptor levels prevent degeneration of CA3 pyramidal neurons.

Figure 5

Assessment of neurodegeneration by Fluoro-Jade C (FJC) staining 5 days after exposure to KA. A–D, Representative images show FJC staining in the cortex and hippocampus of AAV-WT mice (A, B) and AAV-Glu-CB1 mice (C, D). Insets show magnifications of FJC-labeled neurons in the cortex (A, C) and the CA3 area (B, D). CPu, caudate putamen; Ctx, cortex; DG, dentate gyrus; LV, lateral ventricle. Bar in D: 250 µm. E, Quantification of FJC-labeled neurons demonstrated comparable levels of neurodegeneration in the cortex in both groups. F, In contrast, degeneration of CA3 pyramidal neurons was blocked in AAV-Glu-CB1 but not in AAV-WT mice (p<0.05, unpaired t test analysis, two-tailed).