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Circular dichroism melting curves of CMP9, CMP9-K, RCMP-K, and their PEG conjugates. CMP9 and CMP9-K peptides exhibited sigmoidal melting transitions indicative of a triple helical structure both as free peptides in solution (left) and after PEG conjugation (right). RCMP-K peptides with a scrambled CMP sequence, G3-PGOGPGPOPOGOGPOPGOOPGGOOPPG-K, did not show triple helical melting transition upon heating.
