Fig. 8.

Induction of MMP-9 and activation of TGF-β by Zta. A: assessing MMP-9 levels in BAL fluid from adenovirus-exposed mice. Equal volumes of BAL fluid from Adv-Zta- (n = 3) and Adv-GFP-treated (n = 2) mice on day 7 postexposure were analyzed by gelatin zymography for MMP-9 activity. B: measurement of active TGF-β in the BAL fluid of mice in the 3 treatment groups. The graph shows the concentration of active TGF-β in pg/ml in the BAL fluid recovered from mice on day 7 postexposure to Adv-Zta, Adv-GFP, or PBS.