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Effect of PKG inhibition [via 10 μM Rp-8-Br-PET-cGMP (PET)] on pial arteriolar responses to the PKG activator 8-pCPT-cGMP (10 and 50 μM) and SNS-induced pial arteriolar dilations (left) as well as dilations elicited by Ado (10 and 100 μM; right). Measurements were obtained before (open bars) and in the presence of (solid bars) PET. Values are means ± SE; n = 6 rats/group. *P < 0.05 vs. initial responses.
