Fig. 3.
Effects of the A2bAR agonist BAY 60-6583 on cardiac contractility (A) and coronary flow (B). Constant pressure-perfused and paced hearts were treated with increasing concentrations (100, 500, and 1,000 nM) of BAY 60-6583. Baseline contractility was measured before drug infusion, and all data are expressed as percent baseline values. Washout measurements were taken 10 min after responses to the 1,000 nM concentration were determined. Data are means ± SE; n ≥ 5 experiments/group. *P < 0.05 vs. baseline values.