Table 2.

Hemodynamic effects of CGS-21680, Iso, and CGS-21680 + Iso

	LVSP, mmHg	+dP/dt, mmHg/s	−dP/dt, mmHg/s	CF, ml/min
CGS-21680 dose response
Baseline	96 ± 6	3,667 ± 424	−2,123 ± 281	2.2 ± 0.1
100 nM	96 ± 8	3,768 ± 590	−2,216 ± 444	3.3 ± 0.3*
500 nM	97 ± 9	3,868 ± 604	−2,307 ± 471	3.3 ± 0.2*
1,000 nM	98 ± 8	3,911 ± 619	−2,384 ± 485	3.5 ± 0.2*
Iso dose response
Baseline	91 ± 5	3,509 ± 202	−2,010 ± 118	2.3 ± 0.1
2 nM	162 ± 7*	7,691 ± 567*	−4,798 ± 392*	3.0 ± 0.1*
10 nM	181 ± 8*	9,845 ± 813*	−6,036 ± 458*	3.2 ± 0.1*
CGS-21680 + Iso dose response
Baseline	91 ± 5	3,305 ± 354	−1956 ± 178	2.5 ± 0.2
200 nM CGS-21680	88 ± 4	3,264 ± 352	−1,902 ± 153	3.5 ± 0.2*
2 nM Iso	152 ± 6*	6,626 ± 703*	−4,581 ± 444*	3.4 ± 0.2*
10 nM Iso	179 ± 8*	9,237 ± 1271*	−5,886 ± 524*	3.4 ± 0.2*

Values are means ± SE. Baseline values were taken before treatment with the A_2aAR agonist CGS21680 or Iso in WT mouse hearts.

^*P < 0.05.