Fig. 5.

A and B: probability density (A) and cumulative probability (B) of spark duration for the standard (solid line) and tetracaine-based (dashed line) parameter sets. Shown are the probabilities of observing a spark of 40 ms or longer in the standard (solid circles) and tetracaine (open circles) cases. C: aggregate flux (J_rel^T, solid line) through release sites in the whole cell model as a function of the Ca²⁺ activation rate constant (k_co) in the single channel RyR model (Eq. 1). The flux due to release sites with a small number of open channels is also shown (N_O = 1 and and N_O = 1 or 2). Open and solid circles indicate the tetracaine and standard parameter sets, respectively. D: release site flux (J_rel^T) jointly distributed with the number of open channels (N_O) for the tetracaine (open bars) and standard (solid bars) parameter sets.