Fig. 7.

Transient effects upon bulk SR [Ca²⁺] (c_sr), mean spark duration, and spark frequency during the simulated application and washout of tetracaine (arrows). The Ca²⁺ activation rate constant was decreased from k_co = 4.5 to 0.5 μM⁻²·s⁻¹ (left arrow) and later restored to its original value (right arrow). *The mean spark duration was not applicable at the indicated time (see text).