Fig. 4.
Effect of benzamil-induced CTGF inhibition plus HCTZ on PSF. A: in the presence of HCTZ, benzamil potentiated the decrease in PSF at 20, 40, and 80 nl/min [**P < 0.01 and ***P < 0.001, HCTZ (○) vs. HCTZ + benzamil (●)], suggesting that, in the presence of HCTZ, 1) CTGF was activated at 20, 40, and 80 nl/min, 2) CTGF antagonized TGF, and 3) when CTGF was absent, TGF was potentiated. B: delta PSF (calculated by taking each PSF at 0, 10, 20, 40, and 80 nl/min and subtracting PSF at 0 nl/min).