Table 1.
WT | mTOR-Tg | |
---|---|---|
Age, wk | 14.0 ± 0.2 | 13.9 ± 0.2 |
Body weight, g | 23.9 ± 0.5 | 22.2 ± 0.6 |
Tibia length, mm | 23.4 ± 0.3 | 23.4 ± 0.2 |
Heart weight, mg | 120.7 ± 3.5 | 119.5 ± 3.2 |
Heart weight/body weight, mg/g | 5.1 ± 0.2 | 5.4 ± 0.2 |
Heart weight/tibia length, mg/mm | 5.2 ± 0.2 | 5.1 ± 0.1 |
Left ventricular diameter in diastole, mm | 2.9 ± 0.1 | 3.0 ± 0.1 |
Left ventricular diameter in systole, mm | 1.3 ± 0.1 | 1.2 ± 0.1 |
Fractional shortening, % | 56 ± 2 | 61 ± 2 |
Heart rate, beats/min | 702 ± 10 | 695 ± 17 |
Values are means ± SE; n = 8 wild-type littermates (WT) and n = 11 transgenic mice with cardiac-specific overexpression of wild-type mTOR (mTOR-Tg).