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. 2010 Sep 1;299(6):C1386–C1397. doi: 10.1152/ajpcell.00211.2010

Fig. 10.

Fig. 10.

Effect of pHo on methyl ammonium (MA+)-induced current. A: in oocytes expressing Rhbg, methyl amine (MA)/MA+ (5 mM) at pHo 7.5 caused an inward current (segment ab) that readily reversed upon removal of MA/MA+ from the bath (segment bc). Raising bath pH to 8.2 did not cause any change in current (segment cd). MA/MA+ at pHo 8.2 caused a significantly larger inward current (segment de) that recovered upon removal of MA/MA+ (segment ef). Lowering bath pH to 6.5 did not cause any change in current (segment fg). MA/MA+ at pHo 6.5 did not cause any inward current (segment gh). No changes in current were detected in subsequent removal of MA/MA+ at pHo 6.5 (segment hi) or upon restoring bath pH to 7.5 (at point i). B: in H2O-injected oocytes, MA/MA+ (5 mM) did not induce any current at pH 7.5 (segment ab), or at pH 8.2 (segment de) or pH 6.5 (segment gh). Changing bath pH from 7.5 to 8.2 or to 6.5 also did not cause any changes in current.