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Thyroid hormone action has no effect on ERK phosphorylation after expression of activated Raf. An activated Raf (ΔRaf) was expressed in neonatal rat cardiomyocytes, and the effect of thyroid hormone action was tested. Western blot shows phospho-ERK in control cells cultured in T3-free media. ΔRaf expression increased phospho-ERK. TR-α1 in the presence of high T3 concentration failed to inhibit ERK phosphorylation.
