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E2 treatment is correlated with an increase in upstream regulators of Th17 Cells. E2 increased (A) IL-12(p40), one of two heteromers making up the IL-23 protein, (B) IL-6, and (C) TNFα, important early mediators of acute lung inflammation that induce IL-17. * p < 0.05 vs control, n = 4.
