Table 2.
Source | Strain | Age, wk | Mb, g | VL, cm3 | Lm, μm | NV(a), 103 mm−3 | h, μm | v(a), 103 μm3 | Sa/Va, cm−1 |
---|---|---|---|---|---|---|---|---|---|
Voswinckel (32) | C57BL/6 | 12–16 | 24.3 | 0.721 | 54 | 37† | 51 | 740 | |
Knudsen (14) | C57BL/6 | 12 | 0.680 | 35 | 14.1 | 39† | 59 | 1150 | |
Soutière (29) | C57BL/6J | 6–8 | 0.95–1.45 | 45–63 | |||||
Fehrenbach (6) | C57BL/6 | 12–14 | 0.432 | 2.7 | |||||
Mitzner (20) | C57BL/6 | 10–12 | 1.2 | 52 | 770 | ||||
Knust (16) | C57BL/6 | 6.5–10 | 20.6 | 0.307 | 85 | 9.6 | 39† | 59 | 470 |
Lee (17) | C57BL/6J | 7–9 | 38 | ||||||
Kang (13) | C57BL/6J | 12 | 1.7 | 55 | |||||
Knudsen (15) | C57BL/6* | 12 | 0.64 | 39 | 915 | ||||
Overall range | 6–16 | 20–25 | 0.4–1.5 | 40–80 | 3–14 | 30–50 | 500–1000 | ||
This study | C57BL/6N | 12–16 | 21–27 | ∼1.2 | 61.7 ± 12 | 3.2 ± 1.3 | 55 ± 8 | 670 ± 133 |
The measured lung volumes varied by a factor of 3, some of which may be due to different inflation levels achieved in fixation.
SPD-deficient mice treated with recombinant SPD;
h = v(alv)1/3.