Table 2.

Morphometric data from microscopic studies from various literature sources obtained by stereological analysis of mouse lungs using animals of different strain, age, and size

Source	Strain	Age, wk	Mb, g	VL, cm3	Lm, μm	NV(a), 103 mm−3	h, μm	v(a), 103 μm3	Sa/Va, cm−1
Voswinckel (32)	C57BL/6	12–16	24.3	0.721	54		37†	51	740
Knudsen (14)	C57BL/6	12		0.680	35	14.1	39†	59	1150
Soutière (29)	C57BL/6J	6–8		0.95–1.45	45–63
Fehrenbach (6)	C57BL/6	12–14		0.432		2.7
Mitzner (20)	C57BL/6	10–12		1.2	52				770
Knust (16)	C57BL/6	6.5–10	20.6	0.307	85	9.6	39†	59	470
Lee (17)	C57BL/6J	7–9			38
Kang (13)	C57BL/6J	12		1.7	55
Knudsen (15)	C57BL/6*	12		0.64	39				915
Overall range		6–16	20–25	0.4–1.5	40–80	3–14	30–50		500–1000
This study	C57BL/6N	12–16	21–27	∼1.2	61.7 ± 12	3.2 ± 1.3	55 ± 8		670 ± 133

The measured lung volumes varied by a factor of 3, some of which may be due to different inflation levels achieved in fixation.

^*SPD-deficient mice treated with recombinant SPD;

^†h = v(alv)^1/3.