Table 1.

Systemic parameters before and after exchange protocol

			Extreme Hemodilution
	Baseline (n = 18)	Moderate Hemodilution (n = 18)	Dex70 (n = 6)	PEG-Hb (n = 6)
Hct, %	49.4 ± 1.0	18.9 ± 0.6†	11.7 ± 0.5†‡	11.4 ± 0.4†‡
Hb, g/dl	14.7 ± 0.4	6.4 ± 0.4†	3.7 ± 0.3†‡	4.9 ± 0.3*†‡
Plasma Hb, g/dl				1.1 ± 0.1
MAP, mmHg	112 ± 8	97 ± 7†	67 ± 6†‡	86 ± 5*†
HR, beats/min	430 ± 20	438 ± 26	403 ± 31	428 ± 29
PO2, Torr	57.3 ± 6.0	76.4 ± 7.0†	101.0 ± 10.6†‡	88.4 ± 7.3*†
PCO2, Torr	53.4 ± 5.1	49.0 ± 4.9†	39.7 ± 6.4†‡	45.0 ± 5.4*†
pH	7.345 ± 0.021	7.357 ± 0.036	7.326 ± 0.029	7.372 ± 0.024*
BE, mmol	3.1 ± 1.4	1.3 ± 1.2†	−4.2 ± 2.0†‡	0.5 ± 1.1*†

Values are means ± SD. Baseline includes all animals in the study. Dex70, 70-kDa dextran; PEG-Hb, polyethylene glycol-conjugated Hb; Hct, systemic hematocrit; MAP, mean arterial blood pressure; PO₂ and PCO₂, arterial PO₂ and PCO₂; BE, arterial base excess.

^*P < 0.05 vs. Dex70.

^†P < 0.05 vs. baseline.

^‡P < 0.05 vs. moderate hemodilution.