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Thermodynamics for ligand binding to AtMTAN1 and EcMTAN.
| Enzyme Ligand | AtMTAN1 SAH | AtMTAN1 ADE | AtMTAN1-E202Q SAH | AtMTAN1-E202Q MTA | EcMTAN-E174Q SAH | EcMTAN-E174Q MTA |
|---|---|---|---|---|---|---|
| Kd(μM) | 24.8 ± 2.6 | 1.7 ± 0.1 | Not detected | 94.8 ± 4.0 | 9.3 ± 0.4 | 4.8 ± 0.4 |
| ΔH (kcal/mol) | −4.4 ± 0.2 | −10.3 ± 0.5 | 5.6 ± 0.3 | −7.9 ± 0.1 | −9.6 ± 0.1 | |
| −TΔS (kcal/mol) | −1.9 | 2.4 | −11.1 | 1.0 | 2.4 | |
| N | 0.99 ± 0.03 | 0.99 ± 0.003 | 0.97 ± 0.04 | 0.94 ± 0.01 | 0.94 ± 0.01 |
