Table 3.
Model | Methods | Cell type | Phases | Time | Outputs | Size |
---|---|---|---|---|---|---|
Achard and De Schutter (2008) | Det. Reac. Elect./GENESIS/Kinetikita | Cerebellar PC | Ind. LTD | 1 s | Ca2+ | L |
Brown et al. (2008) | Det. Reac. Diff./Virtual Cellb | Cerebellar PC | LTD | 0.4–2 s | IP3 | M |
Doi et al. (2005) | Det. Reac./GENESIS/Kinetikita | Cerebellar PC | Ind. LTD | 0.2–1 s | Ca2+ | L |
Fiala et al. (1996) | Det. Reac. Elect. | Cerebellar PC | Ind. LTD | M | ||
Hellgren Kotaleski and Blackwell (2002) | Det. Reac. Diff./XPPc | Cerebellar PC | LTD | 1–5 s | Ca2+ | S |
Hellgren Kotaleski et al. (2002) | Det. Reac. Diff./XPPc | Cerebellar PC | Ind. LTD | 5–30 s | PKC | M |
Hernjak et al. (2005) | Det. Reac. Diff./Virtual Cellb | Cerebellar PC | Ind. LTD | 0.1–4 s | Ca2+ | M |
Holthoff et al. (2002) | Det. Reac. Diff. Elect./MATLAB® | Neocortical layer V PN | Ind. LTD | 0.5 s | Ca2+ | S |
Kuroda et al. (2001) | Det. Reac./GENESIS/Kinetikita | Cerebellar PC | Ind. STD/E-,L-LTD | 15–100 min | AMPAR | L |
Murzina (2004) | Det. Reac. Diff. Elect. | Cerebellar PC | Ind. LTD | Kinase, receptor | M | |
Ogasawara et al. (2007) | Det. Reac. Diff. Elect. | Cerebellar PC | Ind./Expr./Maint. LTD | 20–60 min | AMPAR | L |
Ogasawara and Kawato (2009) | Det. Stoch. Reac. | Cerebellar PC | Ind./Maint. LTD | 10 s to 70 min | Kinase | S |
Schmidt et al. (2007) | Det. Reac. Diff./Mathematica, FEMLAB | Cerebellar PC | Ind. LTD | 0.2–4 s | Ca2+, CaM | L |
Schmidt and Eilers (2009) | Det. Reac. Diff./Mathematica | Cerebellar PC | Ind. LTD | 0.04–3 s | Ca2+, CaM | S |
Steuber and Willshaw (2004) | Det. Reac. Elect. | Cerebellar PC | Ind. LTD | S | ||
Tanaka et al. (2007) | Det. Reac. | Cerebellar PC | Ind. LTD | AMPAR | M | |
Yang et al. (2001) | Det. Reac. Elect./GENESIS/Chemesisd | Cerebellar PC | Ind. LTD | 10–100 s | PKC | L |
Models are in alphabetical order by the first author and according to the publication month and year. Tabulated characteristics are the method and model types (Det., Stoch., Reac., Diff., Elect., and simulation environment), cell type, phases of LTD, time required for the dynamics of the model to reach a steady state, model outputs, and size of the model based on the number of different chemical species or other model variables (S, M, L). All abbreviations are given in the list of abbreviations.
aGENESIS/Kinetikit (http://www.genesis-sim.org/GENESIS/; http://www.ncbs.res.in/index.php?option=com_content&task=view&id=307; Bower and Beeman, 1998; Bhalla, 2002c).
bVirtual Cell (http://vcell.org; Schaff et al., 1997; Slepchenko et al., 2003).
cXPP (http://www.math.pitt.edu/~bard/xpp/xpp.html; Ermentrout, 2002).
dGENESIS/Chemesis (http://www.genesis-sim.org/GENESIS/; http://krasnow.gmu.edu/CENlab/software.html; Bower and Beeman, 1998; Blackwell and Hellgren Kotaleski, 2002).