Table 3.
Biomarkers for cell injury, organ dysfunction, and Hsp-72 release according to the outcome in severe heatstroke
| Variable | Baseline | T + 3 h | P value | ||
|---|---|---|---|---|---|
| Survivors | Non-survivors | Survivors | Non-survivors | ||
| Urea (mM) | 2 (2–3) | 2 (2–4) | 6 (5–7) | 9 (8–11) | 0.009 |
| Creatinine (µM) | 55 (34–56) | 54 (53–57) | 109 (103–134) | 167 (167–184) | 0.001 |
| CK (U/L) | 535 (259–739) | 571 (445–606) | 2064 (936–2232) | 3057 (2677–4098) | 0.0008 |
| AST (U/L) | 26 (18–29) | 32 (27–33) | 190 (115–196) | 242 (239–382) | 0.0008 |
| ALT (U/L) | 18 (13–34) | 23 (23–23) | 35 (34–57) | 117 (104–186) | 0.0008 |
| Troponin (µg/L) | 0.01 (0.01–0.01) | 0.01 (0.01–0.01) | 0.70 (0.43–1.07) | 11.33 (5.45–17.22) | 0.009 |
| Platelet (109/L) | 498 (476–529) | 516 (487–545) | 271 (237–337) | 183 (182–219) | 0.0003 |
| d-dimer (µg/ml) | 145 (54–193) | 183 (123–224) | 750 (441–861) | 2793 (1796–4210) | 0.0008 |
| Hemoglobin (g/L) | 127 (124–132) | 124 (120–129) | 136 (133–140) | 133 (123–150) | 0.126 |
| Hsp–72 (ng/ml) | 5 (2–9) | 3 (0–6) | 75 (74–94) | 145 (121–169) | 0.004 |
Values represent median±IQR changes in blood urea, creatinine, creatine kinase (CK), aspartic aminotransferase (AST), alanine aminotransferase (ALT), troponin, platelet, d-dimer, hemoglobin, and Hsp-72. Friedman test was used to compare the difference overtime between survivors (n = 3) and non-survivors (n = 6). Data were considered significant at P < 0.05