Table 3.
Correlation between loss of heterozygosity at chromosome 18q, microsatellite instability and clinicopathologic variables of patients n (%)
| Characteristics | Cases | LOH (+) | LOH (-) | P value | MSI-H (%) | MSI-L/MSS (%) | P value |
| Gender | 0.662 | 0.272 | |||||
| Male | 63 (61.8) | 27 | 36 | 9 | 54 | ||
| Female | 39 (38.2) | 23 | 16 | 9 | 30 | ||
| Age (yr) | 0.435 | 0.111 | |||||
| ≤ 60 | 58 (56.9) | 32 | 26 | 11 | 47 | ||
| > 60 | 44 (43.1) | 18 | 26 | 7 | 37 | ||
| Tumor site | 0.023 | < 0.001 | |||||
| Right colon | 46 (45.1) | 13 | 33 | 15 | 31 | ||
| Left colon | 56 (54.9) | 37 | 19 | 3 | 53 | ||
| Tumor size (cm) | 0.232 | 0.327 | |||||
| < 5 | 48 (47.1) | 28 | 20 | 8 | 40 | ||
| ≥ 5 | 54 (52.9) | 22 | 32 | 10 | 44 | ||
| Grade | 0.016 | 0.047 | |||||
| Well/moderately differentiated | 78 (76.5) | 34 | 44 | 15 | 63 | ||
| Poorly differentiated | 24 (23.5) | 16 | 8 | 3 | 21 | ||
| Histologic features | 0.005 | 0.004 | |||||
| Adenocarcinoma | 77 (75.5) | 44 | 33 | 5 | 72 | ||
| Mucinous | 25 (24.5) | 6 | 19 | 13 | 12 | ||
| pT stage | 0.126 | 0.272 | |||||
| T3 | 61 (59.8) | 33 | 28 | 11 | 50 | ||
| T4 | 41 (40.2) | 17 | 24 | 7 | 34 | ||
| Chemotherapy | 0.650 | 0.782 | |||||
| No | 17 (16.7) | 10 | 7 | 4 | 13 | ||
| Yes | 85 (83.3) | 40 | 45 | 14 | 71 |
LOH: Loss of heterozygosity; MSI-L: Low frequency microsatellite instability; MSI-H: High frequency of microsatellite instability; MSS: Microsatellite stable.