Skip to main content
. 2010 Dec 22;121(1):132–147. doi: 10.1172/JCI42912

Figure 11. Transient macrophage depletion blocks lung metastasis without affecting primary growth.

Figure 11

(A) Scatter plot of the incidence and number of lung metastases that developed after tail vein injection of UMUC3 cells in nude mice treated with liposome-encapsulated clodronate (Clod) or empty liposome vehicle (LipV). P < 0.01, Student’s t test. (B) Quantification of mac2 immunostaining of lung tissues showed a significant decrease in macrophage infiltration of lung metastatic foci (In-tumor) and surrounding lung tissues (parenchyma). (C) Scatter plot of the incidence and volume of s.c. tumors grown after injection of UMUC3 cells into nude mice treated with liposome Clod or LipV. (D) Quantification of mac2 immunostaining of s.c. tumors. *P < 0.01, Student’s t test.