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. 2010 Dec 22;121(1):106–112. doi: 10.1172/JCI43752

Figure 2. LOH on chromosome 10 of DN T cells from 4 patients carrying germline heterozygous TNFRSF6 mutations.

Figure 2

(A) Polymorphic markers used for LOH characterization. Each allele is represented by the symbol I. Horizontal bars indicate the upstream LOH region in DN T cells. NI, not informative. (B) An array comparative genome hybridization profile of chromosome 10, showing the LOH (phenotype A/A or B/B but no heterozygosity A/B) and the stable allele copy number (the numbers above the schema depicted the allele copy number: 2 copies along the entire chromosome) that are characteristic of UPD (duplication of the mutant allele with loss of the wild-type allele) in DN T cells of patients 4, 6, and 7. The arrowhead indicates the upstream site of LOH.