Skip to main content
. 2010 Dec 13;121(1):249–264. doi: 10.1172/JCI43964

Figure 10. mCII707–721–specific NKT cells suppress Th1 cell–mediated immune responses.

Figure 10

(A and B) In vivo activation of mCII707–721–specific NKT cells significantly reduced Th1-driven inflammation due to DTH induced by rat CII, assessed by histopathological scoring of tissue inflammation. Data are mean ± SD, n = 6 mice per group. *P ≤ 0.05. Original magnification, ×100. (C) DTH response in WT (B10.Q) is significantly lower than in CD1d–/– mice. While mCII707–721 vaccination dampens DTH reaction, the mCI707–721–negative control peptide is inadequate to exert antiinflammatory effects. DTH response (ear swelling) was calculated by subtracting the thickness of the right ear from that of the left ear. Data are mean ± SEM, n = 4–5 mice per group. *P ≤ 0.05.