Figure 11. Activation of mCII_707–721–specific CD1d-restricted NKT cells in vivo significantly reduces Th2-mediated responses to OVA.

(A–D) Expression of IL-4, IL-5, IL-13, and IgE were all significantly reduced in BALF of mCII_707–721–vaccinated B10.Q mice compared with all control-vaccinated groups of mice. CD1d^–/– mice lack such mCII_707–721–mediated antiinflammatory effects. Data are mean ± SD, n = 4–5 mice per group. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.