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. 2010 Dec 13;121(1):249–264. doi: 10.1172/JCI43964

Figure 12. Activation of mCII707–721–specific NKT cells suppresses arthritis.

Figure 12

(A) Prevaccination of B10.Q mice with mCII707–721 significantly reduced severity by CIA clinical scoring compared with control peptide (mCI707–721) vaccination (14 mice per mCI707–721 group, 19 mice per mCII707–721 group; *P ≤ 0.05). (B) Histological arthritic scores by H&E staining of joints. Data are mean ± SD, n = 5. **P ≤ 0.01. (C) Histological scores of percentage of IFN-γ–, IL-4–, and TNF-α–positive cells were significantly reduced in the mCII707–721–vaccinated group. Data are mean ± SD, n = 5. *P ≤ 0.05. (D) Suppression of arthritis was associated with reduced CD4+ T cell–infiltrating cells, IFN-γ–, and IL-4–producing cells by immunohistochemistry staining of joints. Red-brown color shows positively stained cells. Scale bar: 100 μm.