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. 2010 Dec 13;121(1):249–264. doi: 10.1172/JCI43964

Figure 7. mCII707–721–specific NKT cells produce cytokines.

Figure 7

(A–D) Higher TGF-β1, IFN-γ, and IL-4 production and lower TNF-α production were seen from mCII707–721–immunized splenocytes compared with all other control groups in WT mice but not in CD1d–/– mice. Spleens were taken from CFA, mCI707–721–, and mCII707–721–immunized mice, then treated with mCII707–721 for 48 hours. Supernatants were taken for ELISAs of TGF-β1, IFN-γ, IL-4, and TNF-α. Data are mean ± SD, n = 5 mice per group. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.