Figure 5. Inhibition of Notch signaling in the second heart field results in aortic regurgitation.
Pulse-wave Doppler analysis from the aorta of E17.5 control (A), Islet1Cre/+;DNMAML (B), control (C), and Mef2c-AHF-Cre;DNMAML (D) embryos. Control embryos are WT littermates of the respective mutants. Arrowheads point to regurgitant flow in mutant embryos.