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. 2010 Dec 1;121(1):96–105. doi: 10.1172/JCI44271

Figure 3. Prdm16 stimulates the development of brown-like adipocytes in subcutaneous WAT.

Figure 3

(A–G) Immunohistochemistry for Ucp1 protein (brown stain) in sections of ingWAT (A–D) and epidWAT (E–G) from 10- to 14-week-old male WT (A and E) and aP2-Prdm16 (B–D, F, and G) mice. (D) High-magnification and representative image of ingWAT from a transgenic animal. Arrowheads depict Ucp1 immunopositive cells that have a unilocular morphology typical of white adipocytes. (H and I) Immunohistochemistry for TH protein in samples of ingWAT from WT (H) and aP2-Prdm16 (I) animals as described above. Original magnification, ×20 (A–C and E–G); ×100 (D, H, and I). (J) Quantification of TH-expressing nerve fibers in WT and transgenic ingWAT. Values are mean ± SEM (n = 20 fields per sample in each of 3 animals per group). **P < 0.01 vs. WT.