Figure 1.

Elements over-represented in circadian-regulated promoters. These are elements found in the promoters of circadian-regulated genes identified by Harmer et al. (2000). Each sequence shown was individually identified as a statistically significant over-represented sequence in circadian gene promoters. The sequences in each aligned group are those we determined to represent the same motif. The P value was determined using the binomial distribution to find the likelihood of the observed number of elements occurring in a randomly chosen set of promoters. The letters bs or ss designate whether the element was detected as over-represented on both strands (bs) or just one strand (ss).