. 2010 Sep 29;299(6):R1463–R1477. doi: 10.1152/ajpregu.00866.2009

Table 1.

Hypoxic pulmonary hypertension in wild-type and Id1-deficient mice

	Normoxia			1-Wk Hypoxia			3-Wk Hypoxia
	Wild type	Id1^+/−	Id1^−/−	Wild type	Id1^+/−	Id1^−/−	Wild type	Id1^+/−	Id1^−/−
RVSP, mmHg	19.96 ± 1.06	20.66 ± 0.84	20.76 ± 0.77	26.18 ± 2.18	24.15 ± 1.50	24.59 ± 0.88	28.12 ± 1.01^a	26.68 ± 1.14^a	28.04 ± 1.29^a
n	10	14	16	9	14	19	19	20	20
Female RVSP, mmHg	19.01 ± 1.58	20.91 ± 1.38	19.81 ± 0.83	23.66 ± 2.61	21.01 ± 1.96^a	23.16 ± 0.83^a	25.75 ± 0.84^a	24.91 ± 1.01^a	25.69 ± 1.46^a
n	6	8	6	4	6	10	10	11	10
Male RVSP, mmHg	21.39 ± 1.09	20.33 ± 0.85	21.33 ± 1.12	28.19 ± 3.27	26.50 ± 1.85^a	26.19 ± 1.51^a	30.75 ± 1.52^a,b	28.85 ± 2.08^a	30.39 ± 1.92^a
n	4	6	10	5	8	9	9	9	10
RV/LV+S, mg/mg	0.257 ± 0.008	0.245 ± 0.005	0.258 ± 0.009	0.291 ± 0.016	0.302 ± 0.011^a	0.339 ± 0.015^a	0.368 ± 0.013^a	0.362 ± 0.009^a	0.360 ± 0.007^a
n	10	20	15	5	14	13	17	22	21
RV/body weight, mg/g	0.186 ± 0.006	0.191 ± 0.004	0.213 ± 0.011	0.246 ± 0.011	0.250 ± 0.008^a	0.263 ± 0.01^a	0.309 ± 0.012^a	0.291 ± 0.009^a	0.288 ± 0.012^a
n	10	20	15	4	14	13	17	22	21
Hematocrit, %	32.50 ± 2.13	35.42 ± 0.92	36.95 ± 0.91	39.75 ± 1.76	47.36 ± 1.56^a	46.76 ± 1.21^a	46.36 ± 1.23^a	50.92 ± 1.45^a	49.33 ± 1.83^a
n	7	21	11	8	11	15	11	13	18
Heart rate, beats/min	421.3 ± 21.1	451.8 ± 21.4	439.1 ± 14.1	408.8 ± 19.5	415.7 ± 9.5	415.8 ± 10.1	418.5 ± 9.3	425.8 ± 12.9	398.0 ± 13.8
n	10	16	16	9	14	20	19	20	20

Values are mean ± SE from wild-type, Id1^+/−, and Id1null mice exposed to normoxia or 1-wk or 3-wk hypoxia. Mouse numbers are indicated (n). RVSP, right ventricular systolic pressure; RV, right ventricle; LV, left ventricle; S, septal.

P < 0.05 vs. corresponding genotype normoxic control; P < 0.05 vs. female wild type 3 wk hypoxia by one-way ANOVA with Bonferroni correction.