Table 2.
Hypoxia-induced pulmonary vascular remodeling and vascular cell proliferation in wild-type and Id1 deficient mice
| Normoxia |
1-Wk Hypoxia |
3-Wk Hypoxia |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Wild type | Id1+/− | Id1−/− | Wild type | Id1+/− | Id1−/− | Wild type | Id1+/− | Id1−/− | |
| Muscularized vessels, % | 20.37 ± 2.99 | 18.31 ± 4.24 | 20.35 ± 3.49 | 53.42 ± 5.18a | 57.68 ± 7.61a | 51.54 ± 5.18a | 45.17 ± 2.29a | 46.32 ± 4.14a | 48.37 ± 6.60a |
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| EC proliferation, PCNA positive/total | 0.007 ± 0.004 | 0.022 ± 0.012 | 0.004 ± 0.004 | 0.071 ± 0.015a | 0.082 ± 0.014a | 0.062 ± 0.017a | ND | ND | ND |
| n | 5 | 6 | 6 | 7 | 5 | 5 | |||
| VSMC proliferation, PCNA positive/total | 0.021 ± 0.009 | 0.018 ± 0.007 | 0.012 ± 0.004 | 0.076 ± 0.010a | 0.119 ± 0.016a | 0.113 ± 0.022a | ND | ND | ND |
| n | 5 | 6 | 6 | 7 | 5 | 5 | |||
Values are means ± SE from wild type, Id1+/−, and Id1 null mice exposed to normoxia or 1-wk or 3-wk hypoxia. Mouse numbers are indicated (n). ND, no data recorded; EC, endothelial cell; VSMC, vascular smooth muscle cell.
a
P < 0.05 vs. corresponding genotype normoxic control by one-way ANOVA with Bonferroni correction.