Effect of trans 10, cis 12-conjugated linoleic acid (10,12-CLA) dose on plasma concentrations of insulin, glucose, and adiponectin. Female FVB mice received 10,12-CLA at doses of 0%, 0.1%, 0.2%, or 0.5% of the diet from day 24 to 49 of age (n = 8 to 10 per treatment). Plasma was collected on day 49 of age. Each bar represents the mean ± SE of 5 to 9 mice. a,b,cBars with different letters are significantly different, P < 0.05.