Table I.
Nonsynonymous to synonymous substitution ratios (dn/ds) for WAKL1-WAKL6 STK, Codon-aligned sequences of a 159-base region overlapping the Ser/Thr kinase active site. EGF, Codon aligned sequences of the regions corresponding to the EGF-like domains. Extracellular, Codon-aligned sequences corresponding to the five variable areas in the central part of the WAKL extracellular region (see Fig. 2). nd, Not determined. In some cases, the proportion of observed synonymous substitutions has reached mutational saturation. As such, dn/ds can not accurately be estimated (Nei and Gojobori, 1986).
| Gene Pair | STK | EGF | Extracellular |
|---|---|---|---|
| WAKL1-WAKL2 | 0.06 | nd | 1.03 |
| WAKL1-WAKL3 | 0.15 | 0.10 | 1.82 |
| WAKL1-WAKL4 | 0.09 | 0.24 | 1.26 |
| WAKL1-WAKL5 | 0.09 | 0.39 | 1.32 |
| WAKL1-WAKL6 | 0.10 | 0.20 | 2.08 |
| WAKL2-WAKL3 | 0.07 | 0.65 | 1.49 |
| WAKL2-WAKL4 | 0.03 | 0.46 | 1.24 |
| WAKL2-WAKL5 | 0.03 | 0.38 | 1.49 |
| WAKL2-WAKL6 | 0.03 | 0.36 | 1.24 |
| WAKL3-WAKL4 | 0.11 | 0.41 | 1.36 |
| WAKL3-WAKL5 | 0.11 | 0.85 | 3.18 |
| WAKL3-WAKL6 | 0.12 | 0.25 | 2.42 |
| WAKL4-WAKL5 | 0.06 | 0.34 | 1.08 |
| WAKL4-WAKL6 | 0.06 | 0.60 | 0.96 |
| WAKL5-WAKL6 | 0.08 | 0.32 | 1.67 |