Tab. 3.
Viscosity of formulation (ηp), component of mucoadhesion (ηb) and the force of mucoadesion (F) in stimulated tear fluid (STF)
| Formulation |
Polymer concentration (W/V, %) |
ηp (cPs)a | ηb (cPs)a | F (dyne/cm2)a | |
|---|---|---|---|---|---|
| Sodium alginate | Sodium CMC | ||||
| GS1 | 0.4 | – | 28.7 ± 2.61 | 10.2 ± 2.10 | 17.03 ± 2.40* |
| GS2 | 0.6 | – | 35.4 ± 3.20 | 16.3 ± 2.65 | 27.22 ± 2.60 |
| GS3 | 0.6 | 0.1 | 43.8 ± 2.54 | 28.2 ± 3.12 | 47.10 ± 3.20 |
| GS4 | 0.6 | 0.25 | 55.6 ± 3.41 | 37.5 ± 3.51 | 62.63 ± 3.45* |
| GS5 | 0.6 | 0.5 | 84.3 ± 2.61 | 52.6 ± 4.21 | 87.84 ± 4.25* |
| GS6 | 0.8 | – | 73.5 ± 4.21 | 43.3 ± 2.50 | 72.31 ± 4.61 |
| GS7 | 1 | – | 106.8 ± 5.61 | 57.7 ± 3.60 | 96.36 ± 3.54 |
| GS8 | 2 | – | 125.7 ± 4.36 | 63.6 ± 4.20 | 106.2 ± 5.70 |
a
Values reported as mean ± SD (n = 3);
*
Significantly different (p < 0.05)