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Inactivation of insulin action in the LID mice is restored by introduction of GHa (LID + GHa mice). (a) A Western blot analysis of insulin-induced phosphorylation of the IR (b), IRS-1 (c), and AKT (d) in muscle. The levels of phosphorylation signals (P) are normalized to total immunoreactivity of IR, IGF-1R, or IRS-1 of n = 4 in each group. (*P < 0.05 compared with unstimulated samples.) AU, arbitrary units.
