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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Lab Invest. 2010 May 10;90(8):1209–1224. doi: 10.1038/labinvest.2010.102

Figure 1.

Figure 1

Sphinganine 1-phosphate administered 0.1 mg/kg i.v. immediately prior to reperfusion and 0.2 mg/kg s.c. 2 hrs after reperfusion (Sphinganine 1-P IR (iv+sc), N=6) or 0.1 mg/kg i.v. immediately prior to reperfusion (Sphinganine 1-P IR (iv), N=6) protects against hepatic (A, ALT) and renal (B, creatinine) injury in C57BL/6 mice subjected to 60 min. liver ischemia and 24 hrs reperfusion. Sphinganine 1-phoshate when only given 2 hrs after reperfusion s.c. (Sphinganine 1-P IR (sc), N=6) did not produce liver or kidney protection. Data are presented as mean ± SEM. *P<0.05 vs. vehicle-treated IR (Vehicle IR) group.