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. 2010 Oct 6;104(6):3009–3020. doi: 10.1152/jn.00466.2010

Fig. 1.

Fig. 1.

PINK1-deficient substantia nigra pars compacta (SNC) dopamine neurons display irregular firing patterns. Representative examples of an individual wild type (A) and PINK1-deficient (B) SNC dopamine neuron showing spontaneous activity (scale bars: cell-attached 25 pA, 1 s; whole cell 10 mV, 1 s), interspike interval plots, and immunohistochemical identification (scale bar: 10 μm) C: PINK1-deficient neurons have a similar rate of firing activity to wild type neurons. However, raw data of CV-ISI for 50 wild type and 68 PINK1-deficient neurons shows that PINK1-deficient mice have a greater proportion of irregularly firing neurons D: comparison of action potential waveforms between wild type and PINK1-deficient neurons reveals a significant reduction in the time-to-peak of the afterhyperpolarization (TTP-AHP; E), indicating a disruption of SK channel-mediated conductances. NS, not significant; * = P < 0.05.