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. 2010 Oct 6;104(6):3009–3020. doi: 10.1152/jn.00466.2010

Fig. 6.

Fig. 6.

HtrA2/omi-deficient SNC dopamine neurons display hyperexcitability ex vivo. A: representative examples of spontaneous firing activity from wild type and HtrA2/omi-deficient neurons. Some HtrA2/omi-deficient neurons have irregular firing and bursts under control conditions. (Scale bars: 10 mV, 1 s) B: raw data of CV-ISI analysis shows HtrA2/omi-deficient mice have a greater number of irregularly firing neurons, without a change in firing rate (C). D: voltage-clamp analysis (using 2 ms depolarizing pulses from −50 to +20 mV) reveals a reduction in SK channel-mediated currents in HtrA2/omi-deficient SNC dopamine neurons compared with wildtype (Scale bars: 50 pA, 50 ms). *, P < 0.05.