Skip to main content
. 2010 Sep 29;104(6):3293–3304. doi: 10.1152/jn.00663.2010

Fig. 2.

Fig. 2.

Mossy fiber stimulation evokes a small GABAA receptor–mediated IPSC in HEGCs and a large GABAA receptor–mediated IPSC in GC-SEs. Top: responses recorded from a representative normotopic dentate granule cell from a control rat (CGC), a normotopic granule cell from a rat subjected to pilocarpine-induced status epilepticus (GC-SE), and an HEGC. The mossy fiber-evoked IPSC, NMDA receptor–mediated EPSC, and AMPA/kainate (KA) receptor–mediated EPSC were recorded sequentially. *Stimulus artifact. Bottom left: the mossy fiber-evoked IPSC was smallest in HEGCs whether measured by amplitude or charge transfer. IPSC charge transfer was greatest in GC-SEs largely because of the longer response duration. *P < 0.05 compared with CGC; **P < 0.001 compared with GC-SE and P = 0.025 compared with CGC by Newman-Keuls test after 1-way ANOVA yielded P < 0.001. ***P < 0.01 compared with CGC or GC-SE by Newman-Keuls test after 1-way ANOVA yielded P = 0.003. Bottom right: the charge transfer ratio of AMPA/kainate receptor–mediated EPSC (AMPA) to GABAA receptor–mediated IPSC (GABA) was significantly greater in HEGCs than in GC-SEs. However, the charge transfer ratios of NMDA receptor–mediated EPSC (NMDA) to AMPA/kainate receptor–mediated EPSC were not significantly different. *P = 0.01 by 2-tailed t-test.